Hemostasis is a physiological method of maintaining blood circulation used by the body. A combination of complex interactions between the blood vessel, the smallest blood cells (thrombocytes) and special proteins in the plasma leads to a stop of bleeding in the event of damage to the blood vessel.
The mechanisms involved in this interaction need to be adjusted to ensure an appropriate balance between the need to stop the bleeding and the risk of blockage of the vessel.
Patients with impaired hemostasis system may be at increased risk of bleeding (hemophilia) or blockage of blood vessels due to the formation of an unwanted clot (thrombosis).
Thanks to our analyzers and other services, Sysmex has considerable experience in helping doctors diagnose patients with hemostatic disorders or therapy in order to prevent the development of bleeding or thrombosis. The range of our analyzers can meet the needs of all types of laboratories, providing the possibility of conducting any tests – from basic to highly specialized.
Coagulation is a complex process
When the walls of the blood vessel are damaged, the vessel narrows, slowing down the blood flow. Damaged cells from the inner wall of the vessel (endothelium) trigger several processes, including the activation of platelets and the blood coagulation mechanism. Activated platelets are coupled together (adgesia) and form complex structures (aggregation) that form the primary hemostatic cork in the wall of the vessel to stop bleeding. Activated platelets also form a surface for the clotting process.
Blood clotting (coagulation) occurs due to the formation of a fibrin network, which, in turn, is the result of the activation of many other blood clotting factors. The fibrin network and hemostatic traffic jam are a safe way to stop bleeding and give the body the opportunity to heal the blood vessel.
Fibrinosis is a process that eliminates the fibrin network after the healing of the blood vessel from injury, as a result of which the unobstructed blood flow is restored.
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